BDBM203869 7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimethyl-1Hpyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid, 5::Mcl-1 inhibitor 5
SMILES Cc1c(c(COc2ccc(B(O)O)c(C=O)c2)nn1C)-c1cccc2c(CCCOc3cccc4ccccc34)c([nH]c12)C(O)=O
InChI Key InChIKey=RMIRRIJMEIKMFL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 203869
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 0.900nM ΔG°: -12.3kcal/mole IC50: 3.40nMpH: 7.4 T: 24°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Eberhard Karls University T£Bingen
Curated by ChEMBL
Eberhard Karls University T£Bingen
Curated by ChEMBL
Affinity DataKd: 0.140nMAssay Description:Binding affinity to MCl-1 (unknown origin) assessed as binding affinity constant for state oneMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Eberhard Karls University T£Bingen
Curated by ChEMBL
Eberhard Karls University T£Bingen
Curated by ChEMBL
Affinity DataEC50: 460nMAssay Description:Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Eberhard Karls University T£Bingen
Curated by ChEMBL
Eberhard Karls University T£Bingen
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Eberhard Karls University T£Bingen
Curated by ChEMBL
Eberhard Karls University T£Bingen
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Eberhard Karls University T£Bingen
Curated by ChEMBL
Eberhard Karls University T£Bingen
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Eberhard Karls University T£Bingen
Curated by ChEMBL
Eberhard Karls University T£Bingen
Curated by ChEMBL
Affinity DataKd: 0.0180nMAssay Description:Binding affinity to MCl-1 (unknown origin) assessed as binding affinity constant for state twoMore data for this Ligand-Target Pair