BDBM203872 7-(3-((3-Acetylphenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid, 8::Mcl-1 inhibitor 8
SMILES CC(=O)c1cccc(OCc2nn(C)c(C)c2-c2cccc3c(CCCOc4cccc5ccccc45)c([nH]c23)C(O)=O)c1
InChI Key InChIKey=GEDJUAKXFJRZSG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 203872
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 64nM ΔG°: -9.77kcal/mole IC50: 237nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Affinity DataIC50: 237nMAssay Description:Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 2.70E+3nMAssay Description:Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescence-labeled H1 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 237nMAssay Description:Half-maximal inhibition of [125I]CCK-33 binding to guinea pig brain(cortex) cholecystokinin receptorMore data for this Ligand-Target Pair