BDBM205487 Cytotoxic conjugates, 4

SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)Nc3ccc(CNC(=O)CCC(=O)O[C@H]([C@@H](NC(=O)c4ccccc4)c4ccccc4)C(=O)O[C@H]4C[C@@]5(O)[C@@H](OC(=O)c6ccccc6)[C@@H]6[C@@]7(CO[C@@H]7C[C@H](O)[C@@]6(C)C(=O)[C@H](OC(C)=O)C(=C4C)C5(C)C)OC(C)=O)cc3)c2c1

InChI Key InChIKey=XTFULHZRZACREF-BXKLEEDPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 205487   

TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM205487(Cytotoxic conjugates, 4)
Affinity DataIC50:  250nMAssay Description:Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM205487(Cytotoxic conjugates, 4)
Affinity DataIC50: >2.50E+4nMAssay Description:Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed