BDBM20586 2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,2,3,4-tetrahydroisoquinolin-6-ol::tetrahydroisoquinoline derivative, 18a

SMILES Oc1ccc2C(N(CCc2c1)c1ccccc1)c1ccc(OCCN2CCCCC2)cc1

InChI Key InChIKey=FMWVCTJKLAVRPB-UHFFFAOYSA-N

Data  8 IC50  4 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 20586   

TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  19nM EC50:  16.5nMpH: 7.4 T: 22°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  346nM EC50:  289nMT: 25°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  19nM EC50:  16.5nMpH: 7.4 T: 22°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  289nMAssay Description:Inhibition of transcriptional activation by human estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  16.5nMAssay Description:Inhibition of transcriptional activation by human estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  346nMAssay Description:Inhibition of binding to human estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  19.0nMAssay Description:Inhibition of binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  346nM EC50:  289nMT: 25°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed