BDBM207632 US9265734, R03::US9796664, Compound R03

SMILES Cc1ccc(cc1)C(=O)NCCCCCC(=O)Nc1ccc(F)cc1N

InChI Key InChIKey=BEFOBMGNAJJGSD-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 207632   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207632(US9265734, R03 | US9796664, Compound R03)
Affinity DataIC50: 17nMAssay Description:Inhibition of human HDAC3/NCOR2 using Acetyl-Lys(Ac)-AMC as substrate measured after 1 hrs by fluorescence release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207632(US9265734, R03 | US9796664, Compound R03)
Affinity DataKi:  196nMAssay Description:Binding affinity to human HDAC3 using Acetyl-Lys(Ac)-AMC as substrate assessed as inhibition constant measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207632(US9265734, R03 | US9796664, Compound R03)
Affinity DataIC50: 560nMAssay Description:Inhibition of human HDAC3/NCOR2 using Acetyl-Lys(Ac)-AMC as substrate preincubated for 3 hrs followed by substrate addition measured after 1 hrs by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207632(US9265734, R03 | US9796664, Compound R03)
Affinity DataKi:  630nMAssay Description:Binding affinity to human HDAC1 using Acetyl-Lys(Ac)-AMC as substrate assessed as inhibition constant measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207632(US9265734, R03 | US9796664, Compound R03)
Affinity DataIC50: 800nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207632(US9265734, R03 | US9796664, Compound R03)
Affinity DataIC50: 800nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207632(US9265734, R03 | US9796664, Compound R03)
Affinity DataIC50: 8.20E+3nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207632(US9265734, R03 | US9796664, Compound R03)
Affinity DataIC50: 8.20E+3nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent