BDBM208812 US9266878, 37a

SMILES Nc1ncnc(N2CCC[C@H]2c2nc3cccc(Cl)c3c(=O)n2-c2ccccc2)c1C#Cc1ccccn1

InChI Key InChIKey=XGLXKKQJPDLKBY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 208812   

LigandPNGBDBM208812(US9266878, 37a)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
US Patent

LigandPNGBDBM208812(US9266878, 37a)
Affinity DataIC50: 550nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
US Patent

LigandPNGBDBM208812(US9266878, 37a)
Affinity DataIC50: 550nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
US Patent

LigandPNGBDBM208812(US9266878, 37a)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
US Patent