BDBM208824 US9266878, 49a
SMILES C[C@H](Nc1ncnc(N)c1C#Cc1cn[nH]c1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 208824
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Calistoga
US Patent
Gilead Calistoga
US Patent
Affinity DataIC50: <100nMpH: 7.4 T: 25°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Gilead Calistoga
US Patent
Gilead Calistoga
US Patent
Affinity DataIC50: <100nMpH: 7.4 T: 25°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Gilead Calistoga
US Patent
Gilead Calistoga
US Patent
Affinity DataIC50: 550nMpH: 7.4 T: 25°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Gilead Calistoga
US Patent
Gilead Calistoga
US Patent
Affinity DataIC50: <100nMpH: 7.4 T: 25°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair