BDBM209056 US9266877, 2

SMILES OC(=O)c1nc(ccc1-c1cnn(Cc2ccncc2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1

InChI Key InChIKey=WBCFKELVKOCTOB-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209056   

TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM209056(US9266877, 2)
Affinity DataKi:  5nMAssay Description:Inhibition of F-Bak (GQVGRQLAIIGDK(6-FAM)INR-amide probe binding to BCL-xl (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM209056(US9266877, 2)
Affinity DataKi:  205nM ΔG°:  -9.12kcal/moleT: 2°CAssay Description:The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent