BDBM210003 US10576087, Compound 2.9::US9273046, 2.9::US9895376, Compound 2.9

SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccncc4[nH]3)ccnc2N1

InChI Key InChIKey=QTUSAODLDZOJAR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 210003   

LigandPNGBDBM210003(US9273046, 2.9 | US9895376, Compound 2.9 | US10576...)
Affinity DataIC50: 4.5nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandPNGBDBM210003(US9273046, 2.9 | US9895376, Compound 2.9 | US10576...)
Affinity DataIC50: 4.5nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
US Patent

LigandPNGBDBM210003(US9273046, 2.9 | US9895376, Compound 2.9 | US10576...)
Affinity DataIC50: 4.5nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Beigene

US Patent
LigandPNGBDBM210003(US9273046, 2.9 | US9895376, Compound 2.9 | US10576...)
Affinity DataIC50: 42nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Beigene

US Patent
LigandPNGBDBM210003(US9273046, 2.9 | US9895376, Compound 2.9 | US10576...)
Affinity DataIC50: 42nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Beigene

US Patent
LigandPNGBDBM210003(US9273046, 2.9 | US9895376, Compound 2.9 | US10576...)
Affinity DataIC50: 42nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent