BDBM21040 (2R,3S,6Z,14S,15S,17R)-6-({benzyl[2-(dimethylamino)ethyl]amino}methylidene)-8,14-dihydroxy-3-(methoxymethyl)-2,15-dimethyl-5,9-dioxo-4-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(10),7-dien-17-yl acetate::17-Hydroxywortmannin Analogue, 17

SMILES COC[C@H]1OC(=O)C(=CN(CCN(C)C)Cc2ccccc2)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C

InChI Key InChIKey=GFPIONWDIWXCMZ-ALDCKAMASA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21040   

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21040((2R,3S,6Z,14S,15S,17R)-6-({benzyl[2-(dimethylamino...)
Affinity DataIC50:  5.60E+3nMAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21040((2R,3S,6Z,14S,15S,17R)-6-({benzyl[2-(dimethylamino...)
Affinity DataIC50:  66nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed