BDBM211763 US9290459, 14A::US9670166, 14A

SMILES CCS(=O)(=O)c1cc(ccc1[C@H]1NC(=O)N(C2=C1C(=O)CC2)c1cccc(c1)C(F)(F)F)C#N

InChI Key InChIKey=RKXZMNHXDSTJNI-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 211763   

TargetNeutrophil elastase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211763(US9290459, 14A | US9670166, 14A)
Affinity DataEC50:  1nMpH: 7.5Assay Description:Various concentrations of the neutrophil elastase inhibitor are incubated with plasma. Subsequently, the enzyme activity is measured using the fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
US Patent

TargetNeutrophil elastase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211763(US9290459, 14A | US9670166, 14A)
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
US Patent

TargetNeutrophil elastase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211763(US9290459, 14A | US9670166, 14A)
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent