BDBM213176 US9278963, 023

SMILES ONC(=O)c1cnc(NC2(CCN(CC2)S(=O)(=O)c2ccccc2)c2ccccc2)nc1

InChI Key InChIKey=ZWDFSVCDKZINBX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 213176   

TargetHistone deacetylase 6(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213176(US9278963, 023)
Affinity DataIC50: 4.60nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213176(US9278963, 023)
Affinity DataIC50: 829nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213176(US9278963, 023)
Affinity DataIC50: 844nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
US Patent

TargetHistone deacetylase 3(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM213176(US9278963, 023)
Affinity DataIC50: 3.55E+3nMpH: 7.4 T: 2°CAssay Description:The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
US Patent