BDBM21404 4-{4-benzyl-2-methyl-3-oxo-1-oxa-4,8-diazaspiro[4.5]decan-8-yl}-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]benzamide::Spirocyclic Oxazolidin-4-one, 18

SMILES CC1OC2(CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN(C)C)CSc3ccccc3)c(c2)[N+]([O-])=O)N(Cc2ccccc2)C1=O

InChI Key InChIKey=YOWVHFCSBZXUDJ-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21404   

TargetBcl-2-like protein 1(Human)
Abbott Laboratories

LigandPNGBDBM21404(4-{4-benzyl-2-methyl-3-oxo-1-oxa-4,8-diazaspiro[4....)
Affinity DataKi:  3.70nM ΔG°:  -11.5kcal/mole EC50: >2.00E+4nMpH: 7.4 T: 2°CAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Abbott Laboratories

LigandPNGBDBM21404(4-{4-benzyl-2-methyl-3-oxo-1-oxa-4,8-diazaspiro[4....)
Affinity DataKi:  9.60nM EC50: >5.00E+4nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed