BDBM214809 US9296734, 10

SMILES NC1=N[C@@](CF)(C[C@H](O1)C(F)(F)F)c1cc(Nc2ncc(F)c3cc(cnc23)C#N)ccc1F

InChI Key InChIKey=LWXHQLQQXIEDPY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 214809   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 214809BDBM214809(US9296734, 10)
Affinity DataIC50: 10.1nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2017
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 214809BDBM214809(US9296734, 10)
Affinity DataIC50: 4.40E+4nMpH: 3.5Assay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2017
Entry Details
US Patent