BDBM217455 US9212182, 431

SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1

InChI Key InChIKey=IPKXOBOEJFTCKO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 217455   

TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 5.05E+3nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 3.20E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed