BDBM220692 US9296741, 281

SMILES CN1CCN(Cc2cc3c(-c4cc(S(C)(=O)=O)ccc4Oc4ccc(F)cc4F)cn(C)c(=O)c3[nH]2)CC1

InChI Key InChIKey=QFNIDPJETIJZKG-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 220692   

TargetBromodomain-containing protein 4 [57-168](Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 220692BDBM220692(US9296741, 281)
Affinity DataKi:  1.80nM ΔG°:  -11.9kcal/molepH: 6.0 T: 2°CAssay Description:A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [352-457](Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 220692BDBM220692(US9296741, 281)
Affinity DataKi:  108nM ΔG°:  -9.50kcal/molepH: 6.0 T: 2°CAssay Description:A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent