BDBM222077 6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]pyridin-8-yl)methoxy)-[1,2,4]triazolo[4,3-b] pyridazine (7e)

SMILES Clc1ccc(Cl)c(c1)-c1cn2cccc(COc3nnc4ccc(Cl)nn34)c2n1

InChI Key InChIKey=VWLARPQJDBXNHQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 222077   

TargetHepatocyte growth factor receptor(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222077BDBM222077(6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 53nMAssay Description:Inhibition of c-MET (unknown origin) incubated for 30 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222077BDBM222077(6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222077BDBM222077(6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 222077BDBM222077(6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 1.23E+4nMAssay Description:The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase/Hepatocyte growth factor receptor(Human)
China Pharmaceutical University

LigandChemical structure of BindingDB Monomer ID 222077BDBM222077(6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 1.35E+4nMAssay Description:The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Iran University of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222077BDBM222077(6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal/Hepatocyte growth factor receptor(Human)
China Pharmaceutical University

LigandChemical structure of BindingDB Monomer ID 222077BDBM222077(6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...)
Affinity DataIC50: 1.56E+4nMAssay Description:The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2017
Entry Details Article
PubMed