BDBM222178 Rilpivirine

SMILES Cc1cc(cc(c1Nc2ccnc(n2)Nc3ccc(cc3)C#N)C)/C=C/C#N

InChI Key InChIKey=YIBOMRUWOWDFLG-UHFFFAOYSA-N

Data  66 IC50  7 EC50

PDB links: 31 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 82 hits for monomerid = 222178   

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataEC50:  0.200nMAssay Description:Inhibition of HIV-1 reverse transcriptase K103N mutant assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of KDR (unknown origin) in cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of HIV-1 reverse transcriptase E138K mutant assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataEC50:  0.400nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase p66/p51 Y181C mutant expressed in Escherichia coli BL21 (DE3) pLysS cells preincubated followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataEC50:  1nMAssay Description:Displacement of [3H](-)-CGP-12177 from adrenergic beta1 receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 1nMAssay Description:Inhibition of HIV1 Reverse transcriptase polymerase assessed as decrease in digoxigenin and biotin-dUTP incorporation into DNA using poly(A)/oligo(dT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of HIV-1 reverse transcriptase Y181C mutant assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 2nMAssay Description:Inhibition of KDR (unknown origin) in cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataEC50:  2.30nMAssay Description:Inhibition of HIV-1 reverse transcriptase Y188L mutant assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataEC50:  3.60nMAssay Description:Inhibition of rilpivirine-resistant HIV1 NL4-3 reverse transcriptase E138K mutant infected in human TZM-b1 cells after 2 days by bright Glo-luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 15nMAssay Description:Inhibition of HIV1 RT V106A/F227L mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 15nMAssay Description:Inhibition of HIV1 RT in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubated for 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation into protein incubated for 1 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant wild type p66/p51 HIV1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 15nMAssay Description:Inhibition of wild-type HIV-1 reverse transcriptase by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 21nMAssay Description:Inhibition of HIV1 RT Y181C mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 22nMAssay Description:Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rA)/oligo(dT)16 as template/primer measured after 40 mins by pico-green based spectrofluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 22nMAssay Description:Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rA)/oligo(dT)16 as template/primer measured after 40 mins by pico-green based spectrofluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 22nMAssay Description:Inhibition of wild type HIV1 p66/p51 reverse transcriptase using poly(rA) as template, oligo(dT)16 as primer and RNA/DNA as substrate measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 23nMAssay Description:Inhibition of HIV1 RT K103N/Y181C mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 24nMAssay Description:Inhibition of HIV1 RT L100I mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 27nMAssay Description:Inhibition of HIV1 RT K103N mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 35nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 35nMAssay Description:Inhibition of HCV NS5A M28V mutant in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 35nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant wild-type HIV-1 reverse transcriptase incubated for 40 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 35nMAssay Description:Inhibition of PAK4-mediated GEF-H1 phosphorylation at Ser810 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 38nMAssay Description:Covalent inhibition of recombinant wild type HIV-1 reverse transcriptase using poly(rA)350/oligo(dT)16 as template/primer preincubated followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 41nMAssay Description:Inhibition of HIV1 RT E138K mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 42nMAssay Description:Inhibition of HIV1 Reverse transcriptase by primer extension-based scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein(HIV-1)
Jaipur National University

LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 68nMT: 2°CAssay Description:To a lysis buffer (20 μl), 4-6 ng recombinant HIV-1-RT was added in separate reaction tubes. Lysis buffer without HIV-1-RT was used as a negative ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 84nMAssay Description:Inhibition of HIV1 RT Y188L mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 160nMAssay Description:Inhibition of HIV1 Reverse transcriptase incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C19(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 335nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 335nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 335nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 335nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 335nMAssay Description:Inhibition of human CYP2C19 using S-mephenytoin as substrate in presence of NADPH incubated for 15 to 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 335nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin substrate incubated for 10 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 340nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using s-mephenytoin as substrate incubated for 15 to 40 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 346nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 346nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 346nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 346nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac substrate incubated for 10 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 346nMAssay Description:Inhibition of human CYP2C9 using tolbutamide as substrate in presence of NADPH incubated for 15 to 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 346nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 350nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using sulfaphenazole as substrate incubated for 15 to 40 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222178BDBM222178(Rilpivirine)
Affinity DataIC50: 430nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
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