BDBM223313 Tiaprofenic acid

SMILES CC(C(O)=O)c1ccc(s1)C(=O)c1ccccc1

InChI Key InChIKey=GUHPRPJDBZHYCJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 223313   

TargetCaspase-1(Human)
University of Colorado

LigandPNGBDBM223313(Tiaprofenic acid)
Affinity DataIC50:  1.60E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCaspase-3(Human)
University of Colorado

LigandPNGBDBM223313(Tiaprofenic acid)
Affinity DataIC50:  810nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM223313(Tiaprofenic acid)
Affinity DataIC50:  2.95E+6nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCaspase-5(Human)
University of Colorado

LigandPNGBDBM223313(Tiaprofenic acid)
Affinity DataIC50:  470nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCaspase-9(Human)
University of Colorado

LigandPNGBDBM223313(Tiaprofenic acid)
Affinity DataIC50:  2.20E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCaspase-4(Human)
University of Colorado

LigandPNGBDBM223313(Tiaprofenic acid)
Affinity DataIC50:  380nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed