BDBM224365 US10080750, Compound 42::US9321760, 42::US9662330, Compound 42

SMILES Cn1cc(cn1)-c1c(N)ncnc1N1CCN(CC1)[C@@H](CN)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=VAIFBJMSMMVFMV-KRWDZBQOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224365   

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM224365(US10080750, Compound 42 | US9321760, 42 | US966233...)
Affinity DataIC50:  6nMpH: 7.5Assay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM224365(US10080750, Compound 42 | US9321760, 42 | US966233...)
Affinity DataIC50:  6nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandPNGBDBM224365(US10080750, Compound 42 | US9321760, 42 | US966233...)
Affinity DataIC50:  6nMpH: 7.5Assay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent