BDBM224851 3-(6-{[(1r)-1- cyclobutylethyl]amino}-8-[1- fluoro-1-(2- fluorophenyl)ethyl]-7-[(trans- 4-methylcyclohexyl)methyl]- 7h-purin-2-yl)-1,2,4- oxadiazol-5(4h)-one (diastereomer 1)::US9540377, 22.62::US9540377, 22.65

SMILES C[C@@H](Nc1nc(nc2nc(n(C[C@H]3CC[C@H](C)CC3)c12)C(C)(F)c1ccccc1F)-c1noc(=O)[nH]1)C1CCC1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224851   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224851(3-(6-{[(1r)-1- cyclobutylethyl]amino}-8-[1- fluoro...)
Affinity DataIC50:  22.6nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224851(3-(6-{[(1r)-1- cyclobutylethyl]amino}-8-[1- fluoro...)
Affinity DataIC50:  0.563nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent