BDBM22560 2-arylbenzimidazole derivative, 6::5-tert-butyl-2-{3-chloro-4-[3-(4-methyl-1,4-diazepan-1-yl)propoxy]phenyl}-1H-1,3-benzodiazole

SMILES CN1CCCN(CCCOc2ccc(-c3nc4ccc(C(C)(C)C)cc4[nH]3)cc2Cl)CC1

InChI Key InChIKey=LNGZQOILOUVGME-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22560   

TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22560BDBM22560(5-tert-butyl-2-{3-chloro-4-[3-(4-methyl-1,4-diazep...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22560BDBM22560(5-tert-butyl-2-{3-chloro-4-[3-(4-methyl-1,4-diazep...)
Affinity DataKi:  26nM ΔG°:  -10.3kcal/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2008
Entry Details Article
PubMed