BDBM226310 (R)-3-((4-(1-(((S)-8-(5-((1S,3S)-2-(2,2- difluoroethyl)-3-methyl-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indol-1-yl)pyrimidin-2- yl)-1-oxa-8-azaspiro[4.5]decan-3- yl)methyl)piperidin-4- yl)phenyl)amino)piperidine-2,6-dione::US20260007681, Compound A66

SMILES C[C@H]9Cc1c([nH]c2ccccc12)[C@H](c8cnc(N3CCC7(CC3)C[C@@H](CN6CCC(c5ccc(N[C@@H]4CCC(=O)NC4=O)cc5)CC6)CO7)nc8)N9CC(F)F

InChI Key InChIKey=RZFDGDVHVIXWFC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226310   

TargetDNA damage-binding protein 1/Protein cereblon(Human)
University Of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 226310BDBM226310((R)-3-((4-(1-(((S)-8-(5-((1S,3S)-2-(2,2- difluoroe...)
Affinity DataIC50: 275nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2026
Entry Details
US Patent