BDBM227695 2-{1-[6-(5-chloropyridin- 3-yl)-7-[(trans-4- methylcyclohexyl)methyl]- 2-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3-yl)-7h- purin-8-yl]-1- fluoroethyl}benzonitrile (racemate)::US9540377, 23.110

SMILES C[C@H]1CC[C@H](Cn2c(nc3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)C(C)(F)c2ccccc2C#N)CC1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227695   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227695(2-{1-[6-(5-chloropyridin- 3-yl)-7-[(trans-4- methy...)
Affinity DataIC50:  0.515nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent