BDBM22787 1-acetyl-2,3-dihydro-1H-indole-2,3-dione::Acetylisatin (Compound 7)::Isatin-based compound, 7

SMILES CC(=O)N1C(=O)C(=O)c2ccccc12

InChI Key InChIKey=LPGDEHBASRKTDG-UHFFFAOYSA-N

Data  5 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 22787   

TargetLiver carboxylesterase 1(Human)
St. Jude Research Hospital

LigandPNGBDBM22787(1-acetyl-2,3-dihydro-1H-indole-2,3-dione | Acetyli...)
Affinity DataKi:  3.60E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Rabbit)
St. Jude Research Hospital

LigandPNGBDBM22787(1-acetyl-2,3-dihydro-1H-indole-2,3-dione | Acetyli...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandPNGBDBM22787(1-acetyl-2,3-dihydro-1H-indole-2,3-dione | Acetyli...)
Affinity DataKi: >1.00E+5nM ΔG°: >-5.45kcal/molepH: 7.4 T: 25°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22787(1-acetyl-2,3-dihydro-1H-indole-2,3-dione | Acetyli...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22787(1-acetyl-2,3-dihydro-1H-indole-2,3-dione | Acetyli...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

LigandPNGBDBM22787(1-acetyl-2,3-dihydro-1H-indole-2,3-dione | Acetyli...)
Affinity DataIC50:  990nMT: 37°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rat)
King Saud University

Curated by ChEMBL
LigandPNGBDBM22787(1-acetyl-2,3-dihydro-1H-indole-2,3-dione | Acetyli...)
Affinity DataIC50:  56nMAssay Description:Inhibition of MAO-A in rat liver mitochondria using serotonin as substrate preincubated with enzyme for 60 mins prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Bovine)
King Saud University

Curated by ChEMBL
LigandPNGBDBM22787(1-acetyl-2,3-dihydro-1H-indole-2,3-dione | Acetyli...)
Affinity DataIC50:  3.80E+5nMAssay Description:Inhibition of MAO-B in bovine brain mitochondria using benzylamine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed