BDBM228236 1-((1r,4r)-4-hydroxycyclohexyl)-3-methyl-8-(6-phenylpyridin-3-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one::US10047084, 25

SMILES Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3cc(-c4ccc(-c5ccccc5)nc4)ccc3ncc21

InChI Key InChIKey=UOSMVGWFXJJPLS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 228236   

TargetSerine/threonine-protein kinase mTOR(Human)
Beijing Forelandpharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228236BDBM228236(US10047084, 25 | 1-((1r,4r)-4-hydroxycyclohexyl)-3...)
Affinity DataIC50: 25nMAssay Description:The inhibition of the mTOR protein kinase activity by the compounds was determined by the enzymatic activity assay in vitro. The detection kit suppli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
US Patent