BDBM228691 US10369153, Compound 218::US9346810, 218

SMILES CC(C)S(=O)(=O)Nc1ccc(nc1)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12

InChI Key InChIKey=YKBZQRXTJNNAKC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 228691   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228691(US9346810, 218 | US10369153, Compound 218)
Affinity DataIC50: 0.0550nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228691(US9346810, 218 | US10369153, Compound 218)
Affinity DataIC50: 0.550nMT: 2°CAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228691(US9346810, 218 | US10369153, Compound 218)
Affinity DataIC50: 100nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM228691(US9346810, 218 | US10369153, Compound 218)
Affinity DataIC50: 550nMAssay Description:JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent