BDBM22970 2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid::CHEMBL320140::Indomethacin derivative, 23

SMILES COc1ccc2n(Cc3ccc(Br)cc3)c(C)c(CC(O)=O)c2c1

InChI Key InChIKey=VYGRRQURXQHVSD-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22970   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50: >6.60E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  2.50E+3nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  3.80E+3nMT: 2°CAssay Description:Inhibition assays in triplicate were performed by preincubating enzyme (60-80 nM) and inhibitors (0-5 mM) for 20 min at 25°C followed by the add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 using whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School of Medicine

LigandPNGBDBM22970(2-{1-[(4-bromophenyl)methyl]-5-methoxy-2-methyl-1H...)
Affinity DataIC50: >6.60E+4nMAssay Description:In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]AA (50 uM) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed