BDBM231625 MLS000544460

SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1

InChI Key InChIKey=VDKNIVFIPSLUFD-RGVLZGJSSA-N

Data  1 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 231625   

TargetEyes absent homolog 2 [253-538](Human)
University of Colorado School of Medicine

LigandPNGBDBM231625(MLS000544460)
Affinity DataIC50:  4.10E+3nMpH: 6.5 T: 25°CAssay Description:Eya activity was measured in 50-μl reactions using black, 96-well, half-volume microtiter plates (Greiner Bio-one) with the substrate OMFP (3-O-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEyes absent homolog 2 [253-538](Human)
University of Colorado School of Medicine

LigandPNGBDBM231625(MLS000544460)
Affinity DataKd:  800nMpH: 6.5 T: 25°CAssay Description:Eya proteins were purified via S200 in isothermal titration calorimetry (ITC) buffer (50mM NaPO4 buffer, pH 6.5, 50 mM NaCl). Inhibitor solutions wer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEyes absent homolog 2 [253-538](Human)
University of Colorado School of Medicine

LigandPNGBDBM231625(MLS000544460)
Affinity DataKd:  6.10E+3nMpH: 6.5 T: 25°CAssay Description:Eya proteins were purified via S200 in isothermal titration calorimetry (ITC) buffer (50mM NaPO4 buffer, pH 6.5, 50 mM NaCl). Inhibitor solutions wer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEyes absent homolog 2 [253-538](Human)
University of Colorado School of Medicine

LigandPNGBDBM231625(MLS000544460)
Affinity DataKd:  2.00E+3nMpH: 6.5 T: 25°CAssay Description:Eya proteins were purified via S200 in isothermal titration calorimetry (ITC) buffer (50mM NaPO4 buffer, pH 6.5, 50 mM NaCl). Inhibitor solutions wer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)