BDBM232964 US9353113, Ref. Ex. 2

SMILES OC(=O)[C@H]1CC[C@H](CC(=O)N2CCc3c(C2)n(Cc2ccc(F)cc2F)c2ncccc32)CC1

InChI Key InChIKey=PMDBHVLDYVKHEL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 232964   

TargetAutotaxin(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM232964(US9353113, Ref. Ex. 2)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of LysoPLD activity of ATX in human plasma assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM232964(US9353113, Ref. Ex. 2)
Affinity DataIC50: 14nMpH: 9.0Assay Description:10 μL of a test compound solution (10% dimethyl sulfoxide) at each concentration and 40 μL of a 5 μg/mL human ENPP2 solution (buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details
US Patent

TargetAutotaxin(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM232964(US9353113, Ref. Ex. 2)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed