BDBM234341 4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydrazinyl)phenyl)-5-phenyl-N-(5-sulphamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide (11)

SMILES CC(=O)C(=NNc1ccc(-n2nc(C(=O)Nc3nnc(S(N)(=O)=O)s3)c(C(=O)c3ccccc3)c2-c2ccccc2)cc1)C(C)=O

InChI Key InChIKey=LQIGBCNHEUVEAQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 234341   

TargetCarbonic anhydrase 2(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234341BDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 80nMAssay Description:Carbonic anhydrase (CA) activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234341BDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 103nMAssay Description:The Ki values were determined as described in the literature [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; B lb l et al., J. Enzyme I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234341BDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 130nMpH: 7.4Assay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234341BDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 330nMAssay Description:Carbonic anhydrase (CA) activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234341BDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 570nMpH: 7.4Assay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234341BDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 572nMAssay Description:The Ki values were determined as described in the literature [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; B lb l et al., J. Enzyme I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed