BDBM234346 Diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-(5-sulphamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate (16)

SMILES CCOC(=O)C(=NNc1ccc(-n2nc(C(=O)Nc3nnc(S(N)(=O)=O)s3)c(C(=O)c3ccccc3)c2-c2ccccc2)cc1)C(=O)OCC

InChI Key InChIKey=ICSZNYVOBFMWEG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 234346   

TargetCarbonic anhydrase 2(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234346BDBM234346(Diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-(5-sulphamoy...)
Affinity DataIC50: 65nMAssay Description:The Ki values were determined as described in the literature [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; B lb l et al., J. Enzyme I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234346BDBM234346(Diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-(5-sulphamoy...)
Affinity DataIC50: 70nMpH: 7.4Assay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234346BDBM234346(Diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-(5-sulphamoy...)
Affinity DataIC50: 300nMAssay Description:The Ki values were determined as described in the literature [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; B lb l et al., J. Enzyme I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234346BDBM234346(Diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-(5-sulphamoy...)
Affinity DataIC50: 380nMpH: 7.4Assay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234346BDBM234346(Diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-(5-sulphamoy...)
Affinity DataIC50: 850nMAssay Description:Carbonic anhydrase (CA) activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Dumlupinar University

LigandChemical structure of BindingDB Monomer ID 234346BDBM234346(Diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-(5-sulphamoy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Carbonic anhydrase (CA) activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed