BDBM23484 CHEMBL410462::hydroxamate deriv., 34::methyl (1R,2S)-2-(hydroxycarbamoyl)-1-({4-[(2-methylquinolin-4-yl)methoxy]phenyl}methyl)cyclopropane-1-carboxylate

SMILES COC(=O)[C@@]1(Cc2ccc(OCc3cc(C)nc4ccccc34)cc2)C[C@@H]1C(=O)NO

InChI Key InChIKey=HJWMYFBKJRVWJY-YKSBVNFPSA-N

Data  2 KI

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 23484   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Athens

Curated by ChEMBL

LigandBDBM23484(CHEMBL410462 | hydroxamate deriv., 34 | methyl (1R...)Copy SMILESCopy InChI

Affinity DataKi:  8nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLDrugBankMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D Structure (crystal)
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TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Human)
Schering-Plough Research Institute

LigandBDBM23484(CHEMBL410462 | hydroxamate deriv., 34 | methyl (1R...)Copy SMILESCopy InChI

Affinity DataKi:  8nMAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLDrugBankMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedMMDB
PDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL