BDBM23487 (1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)methoxy]phenyl}methyl)cyclopropane-1,2-dicarboxamide::BMCL1954 Compound 3::hydroxamate deriv., 78

SMILES Cc1cc(COc2ccc(C[C@@]3(C[C@@H]3C(=O)NO)C(N)=O)cc2)c2ccccc2n1

InChI Key InChIKey=ZWPPXQSIUHCIOD-XXBNENTESA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 23487   

LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  3nMAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  3nM ΔG°:  -11.5kcal/molepH: 7.3 T: 22°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetStromelysin-1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrilysin(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  1.00E+6nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  2.40E+6nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi: >1.00E+7nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi: >1.00E+7nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed