BDBM234971 4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piperidin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)-n-(cyanomethyl)benzamide::US9556148, 42

SMILES Cc1cnc(Nc2ccc(cc2)N2CCC(CC2)N2CCC3(CCCO3)CC2)nc1-c1ccc(cc1)C(=O)NCC#N

InChI Key InChIKey=DCBUMPUGEWWUOS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 234971   

TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234971(4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piper...)
Affinity DataIC50: 2.5nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234971(4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piper...)
Affinity DataIC50: 4.30nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234971(4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piper...)
Affinity DataIC50: 59nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent