BDBM234972 US9556148, 43::n-(cyanomethyl)-4-(5-methyl-2-((4-(4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)benzamide

SMILES Cc1nnc(o1)C1CCN(CC1)c1ccc(Nc2ncc(C)c(n2)-c2ccc(cc2)C(=O)NCC#N)cc1

InChI Key InChIKey=MKRRTJNUNROQLR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 234972   

TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234972(n-(cyanomethyl)-4-(5-methyl-2-((4-(4-(5-methyl-1,3...)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234972(n-(cyanomethyl)-4-(5-methyl-2-((4-(4-(5-methyl-1,3...)
Affinity DataIC50: 2.60nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234972(n-(cyanomethyl)-4-(5-methyl-2-((4-(4-(5-methyl-1,3...)
Affinity DataIC50: 52.3nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent