BDBM235891 US9364482, 72

SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2c(cc1C)nnn(Cc1ccc(F)cc1)c2=O)-c1ccc(F)cc1

InChI Key InChIKey=BNSTVDKRZVYCPF-UHFFFAOYSA-N

Data  2 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 235891   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235891(US9364482, 72)
Affinity DataEC50:  1nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 4a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235891(US9364482, 72)
Affinity DataEC50:  1.10nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 3a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235891(US9364482, 72)
Affinity DataEC50:  2.30nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235891(US9364482, 72)
Affinity DataEC50:  4.40nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1b by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235891(US9364482, 72)
Affinity DataEC50:  4.70nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 2b by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235891(US9364482, 72)
Affinity DataEC50:  6.20nMAssay Description:Non-nucleoside inhibition of NS5B polymerase C316Y mutant in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetGenome polyprotein [1027-1711](HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM235891(US9364482, 72)
Affinity DataIC50: 6.47nMAssay Description:Stable neomycin phosphotransferase encoding replicons-harboring cell lines were used, so all cell lines were maintained under G418 selection prior to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235891(US9364482, 72)
Affinity DataEC50:  6.60nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 2a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetGenome polyprotein [1027-1711](HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM235891(US9364482, 72)
Affinity DataIC50: 8.62nMAssay Description:Stable neomycin phosphotransferase encoding replicons-harboring cell lines were used, so all cell lines were maintained under G418 selection prior to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM235891(US9364482, 72)
Affinity DataEC50:  16nMAssay Description:Non-nucleoside inhibition of NS5B polymerase S365A mutant in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed