BDBM237183 Ranitidine

SMILES CN\C(NCCSCc1ccc(CN(C)C)o1)=C/[N+]([O-])=O

InChI Key InChIKey=VMXUWOKSQNHOCA-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 237183   

TargetHistamine H2 receptor(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM237183(Ranitidine)
Affinity DataKi:  89nMAssay Description:Antagonist activity at histamine H2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 1(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM237183(Ranitidine)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of OCT1(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT1 using ASP+ as substrate incubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Erzincan University

LigandPNGBDBM237183(Ranitidine)
Affinity DataKi:  2.97E+4nM ΔG°:  -6.17kcal/mole IC50: 6.61E+4nMpH: 7.4 T: 2°CAssay Description:CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Erzincan University

LigandPNGBDBM237183(Ranitidine)
Affinity DataKi:  5.47E+4nM ΔG°:  -5.81kcal/mole IC50: 5.55E+4nMpH: 7.4 T: 2°CAssay Description:CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM237183(Ranitidine)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM237183(Ranitidine)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 2(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM237183(Ranitidine)
Affinity DataIC50: 1.62E+6nMAssay Description:Inhibition of OCT2(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT2 using ASP+ as substrate incubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed