BDBM238255 US10336741, Example 43::US10882855, Example 43::US9394250, 43::US9585881, Example 43

SMILES O=C(Nc1ccc2nn[nH]c2c1)[C@@H]1C[C@H](N2CCOCC2)CN1C(=O)/C=C/c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=KGAPLUOXQZIAGC-UHFFFAOYSA-N

Data  12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 238255   

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/2/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/1/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/21/2020
Entry Details
Copy BDB DOIUS Patent

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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/17/2017
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/1/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/1/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/2/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/2/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/17/2017
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/21/2020
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetCoagulation factor X(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/21/2020
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetProthrombin(Human)
Ono Pharmaceutical

US Patent

LigandBDBM238255(US9394250, 43 | US9585881, Example 43 | US10336741...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Human Factor Xa (American Diagnostica Inc.) and human thrombin (Sigma) activities were measured at the enzyme concentrations of 0.18 U/mL and 0.12 U/...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/17/2017
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL