BDBM239812 Roche-Dataset for PDE10A, Compound 227::US9394311, 95

SMILES Cc1c(Cl)cc(OC(F)F)c2nc(CCc3nc(nn3C)N3CCCC3)nn12

InChI Key InChIKey=MNFUXWSTNGALPY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 239812   

LigandPNGBDBM239812(Roche-Dataset for PDE10A, Compound 227 | US9394311...)
Affinity DataIC50:  0.230nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM239812(Roche-Dataset for PDE10A, Compound 227 | US9394311...)
Affinity DataIC50:  0.230nMT: 25°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent