BDBM24065 1-[(5S)-3-(2,5-difluorophenyl)-5-(3-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one::3,5-diaryl-4,5-dihydropyrazole, 1::CHEMBL195232

SMILES CC(=O)N1N=C(C[C@H]1c1cccc(O)c1)c1cc(F)ccc1F

InChI Key InChIKey=YLSHULIHKQRKEM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 24065   

TargetCaspase-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24065(CHEMBL195232 | 1-[(5S)-3-(2,5-difluorophenyl)-5-(3...)
Affinity DataIC50: 15nMAssay Description:Inhibitory concentration towards caspase-3 induction in human A2780 ovarian carcinoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM24065(CHEMBL195232 | 1-[(5S)-3-(2,5-difluorophenyl)-5-(3...)
Affinity DataIC50: 24.7nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24065(CHEMBL195232 | 1-[(5S)-3-(2,5-difluorophenyl)-5-(3...)
Affinity DataIC50: 26nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

LigandPNGBDBM24065(CHEMBL195232 | 1-[(5S)-3-(2,5-difluorophenyl)-5-(3...)
Affinity DataIC50: 26.4nMpH: 7.4 T: 2°CAssay Description:The hERG IC50 values were determined by radioligand competition experiments using membrane preparations from human embryonic kidney cells that stably...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed