BDBM241331 US10479788, Example 175::US11046688, Example 175::US9409907, 175

SMILES COc1cc(ccc1Nc1ncc2ccnc(NCC(C)(C)C)c2n1)-c1nncn1C

InChI Key InChIKey=VZBGYKSZEPEEDD-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 241331   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM241331(US10479788, Example 175 | US11046688, Example 175 ...)
Affinity DataKi:  8nMAssay Description:Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM241331(US10479788, Example 175 | US11046688, Example 175 ...)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDual specificity protein kinase TTK(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM241331(US10479788, Example 175 | US11046688, Example 175 ...)
Affinity DataIC50:  2nMAssay Description:The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDual specificity protein kinase TTK(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM241331(US10479788, Example 175 | US11046688, Example 175 ...)
Affinity DataIC50:  2nMpH: 7.0 T: 25°CAssay Description:The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetDual specificity protein kinase TTK(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM241331(US10479788, Example 175 | US11046688, Example 175 ...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of MPS1 autophosphorylation at Thr33/Ser37 in human HCT116 cells after 2 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed