BDBM241619 US9409915, 11::US9718820, Compound 11

SMILES COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1Cl

InChI Key InChIKey=BWNRDOOTXFSNPN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 241619   

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM241619(US9409915, 11 | US9718820, Compound 11)
Affinity DataIC50:  3.5nMT: 37°CAssay Description:HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTransient receptor potential cation channel subfamily M member 8(Human)
Instituto De Qu£Mica M£Dica

Curated by ChEMBL
LigandPNGBDBM241619(US9409915, 11 | US9718820, Compound 11)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at human TRMP8 incubated for 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM241619(US9409915, 11 | US9718820, Compound 11)
Affinity DataIC50:  3.5nMT: 25°CAssay Description:HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent