BDBM241941 US9422333, I-6

SMILES CC(C)=CC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N1CC2[C@@H]([C@H]1C(=O)NC(CC1CCC1)C(=O)C(N)=O)C2(C)C

InChI Key InChIKey=NGJMDEKIIPSHMC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 241941   

TargetGenome polyprotein [1027-1207,D168A](Hepacivirus C)
Celgene Avilomics Research

US Patent
LigandChemical structure of BindingDB Monomer ID 241941BDBM241941(US9422333, I-6)
Affinity DataIC50: 25nMpH: 7.8 T: 2°CAssay Description:The protocol is a modified FRET-based assay (v_02) from In Vitro Resistance Studies of HCV Serine Protease Inhibitors, 2004, JBC, vol. 279, No. 17, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Celgene Avilomics Research

US Patent
LigandChemical structure of BindingDB Monomer ID 241941BDBM241941(US9422333, I-6)
Affinity DataIC50: 53nMpH: 7.8 T: 2°CAssay Description:The protocol is a modified FRET-based assay (v_02) from In Vitro Resistance Studies of HCV Serine Protease Inhibitors, 2004, JBC, vol. 279, No. 17, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetGenome polyprotein [1027-1207,D168A](Hepacivirus C)
Celgene Avilomics Research

US Patent
LigandChemical structure of BindingDB Monomer ID 241941BDBM241941(US9422333, I-6)
Affinity DataIC50: 321nMpH: 7.5Assay Description:The protocol is a modified FRET-based assay (v_03) developed to evaluate compound potency, rank-order and resistance profiles against wild type and C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Celgene Avilomics Research

US Patent
LigandChemical structure of BindingDB Monomer ID 241941BDBM241941(US9422333, I-6)
Affinity DataIC50: 456nMpH: 7.5Assay Description:The protocol is a modified FRET-based assay (v_03) developed to evaluate compound potency, rank-order and resistance profiles against wild type and C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetGenome polyprotein [1027-1207,R155K](Hepacivirus C)
Celgene Avilomics Research

US Patent
LigandChemical structure of BindingDB Monomer ID 241941BDBM241941(US9422333, I-6)
Affinity DataIC50: 1.05E+3nMpH: 7.5Assay Description:The protocol is a modified FRET-based assay (v_03) developed to evaluate compound potency, rank-order and resistance profiles against wild type and C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetGenome polyprotein [1027-1207,C159S](Hepacivirus C)
Celgene Avilomics Research

US Patent
LigandChemical structure of BindingDB Monomer ID 241941BDBM241941(US9422333, I-6)
Affinity DataIC50: 2.07E+3nMpH: 7.5Assay Description:The protocol is a modified FRET-based assay (v_03) developed to evaluate compound potency, rank-order and resistance profiles against wild type and C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetGenome polyprotein [1027-1207,A156S](Hepacivirus C)
Celgene Avilomics Research

US Patent
LigandChemical structure of BindingDB Monomer ID 241941BDBM241941(US9422333, I-6)
Affinity DataIC50: 3.00E+3nMpH: 7.5Assay Description:The protocol is a modified FRET-based assay (v_03) developed to evaluate compound potency, rank-order and resistance profiles against wild type and C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent