BDBM243271 3-(3,5-dimethyl-4- isoxazolyl)-7-((1,1-dioxido- 4- thiomorpholinyl)carbonyl)- 9-(methylsulfonyl)-9H- carbazole-1-carboxamide::US10053454, Example 15::US10196387, Example 15

SMILES Cc1noc(C)c1-c1cc(C(N)=O)c2n(c3cc(ccc3c2c1)C(=O)N1CCS(=O)(=O)CC1)S(C)(=O)=O

InChI Key InChIKey=OBSSOFKXOOWZIS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 243271   

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 243271BDBM243271(3-(3,5-dimethyl-4- isoxazolyl)-7-((1,1-dioxido- 4-...)
Affinity DataIC50: 5.00E+3nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 243271BDBM243271(3-(3,5-dimethyl-4- isoxazolyl)-7-((1,1-dioxido- 4-...)
Affinity DataIC50: 5.00E+3nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 243271BDBM243271(3-(3,5-dimethyl-4- isoxazolyl)-7-((1,1-dioxido- 4-...)
Affinity DataIC50: 5.00E+3nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent