BDBM243278 9-(cyclopropylsulfonyl)-3-(3,5- dimethyl-4-isoxazolyl)-7-((3- methoxy-1-azetidinyl)carbonyl)-9H- carbazole-1-carboxamide::US10053454, Example 22::US10196387, Example 22

SMILES COC1CN(C1)C(=O)c1ccc2c(c1)n(c1c(cc(cc21)-c1c(C)noc1C)C(N)=O)S(=O)(=O)C1CC1

InChI Key InChIKey=HVPCIHCAUVAGAQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 243278   

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243278(9-(cyclopropylsulfonyl)-3-(3,5- dimethyl-4-isoxazo...)
Affinity DataIC50: <50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243278(9-(cyclopropylsulfonyl)-3-(3,5- dimethyl-4-isoxazo...)
Affinity DataIC50: <50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243278(9-(cyclopropylsulfonyl)-3-(3,5- dimethyl-4-isoxazo...)
Affinity DataIC50: <50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent