BDBM243470 US9427440, 18
SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O
InChI Key InChIKey=LTHKMHZATSPXJT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 243470
Affinity DataEC50: 79nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKon: 0.0000480M-1s-1 Koff: 2.00E+4s-1pH: 7.4 T: 25°CAssay Description:All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...More data for this Ligand-Target Pair
Affinity DataKd: 2.40nMpH: 7.4 T: 25°CAssay Description:All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMT: 25°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair