BDBM24463 N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-[(2S)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide::Substituted Pyrazolone, 5
SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@H](C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
InChI Key InChIKey=OHLUERTUZNIQEE-SFHVURJKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 24463
Affinity DataKi: 1.10nM ΔG°: -12.1kcal/molepH: 7.4 T: 22°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 386nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 386nM ΔG°: -8.66kcal/molepH: 7.4 T: 22°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataKi: 695nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair