BDBM24550 3-{2-[(3Z)-5-{[(3-chloro-4-fluorophenyl)methyl]sulfamoyl}-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid::Oxindole scaffold, 10o

SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(F)c(Cl)c2)c1

InChI Key InChIKey=LFNWLAPCMNMILF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24550   

LigandPNGBDBM24550(3-{2-[(3Z)-5-{[(3-chloro-4-fluorophenyl)methyl]sul...)
Affinity DataIC50:  4.80E+3nMpH: 7.0 T: 22°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Moffitt Cancer Center

LigandPNGBDBM24550(3-{2-[(3Z)-5-{[(3-chloro-4-fluorophenyl)methyl]sul...)
Affinity DataIC50:  5.49E+4nMAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24550(3-{2-[(3Z)-5-{[(3-chloro-4-fluorophenyl)methyl]sul...)
Affinity DataIC50:  1.23E+5nMAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed