BDBM24597 Benzimidazole carbamate analogue, 1::ethyl N-{5-[(E)-2-(4-hydroxyphenyl)ethenyl]-1H-1,3-benzodiazol-2-yl}carbamate

SMILES CCOC(=O)Nc1nc2ccc(C=Cc3ccc(O)cc3)cc2[nH]1

InChI Key InChIKey=UMJORYMLIJNHBX-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24597   

TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24597BDBM24597(ethyl N-{5-[(E)-2-(4-hydroxyphenyl)ethenyl]-1H-1,3...)
Affinity DataKi:  2.00E+3nM ΔG°:  -7.90kcal/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24597BDBM24597(ethyl N-{5-[(E)-2-(4-hydroxyphenyl)ethenyl]-1H-1,3...)
Affinity DataKi:  2.00E+4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24597BDBM24597(ethyl N-{5-[(E)-2-(4-hydroxyphenyl)ethenyl]-1H-1,3...)
Affinity DataKi: >6.00E+4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed